He passed away on Friday at his Los Angeles home with his wife, Taylor Simone, and other family members by his side.
His family confirmed his death on Twitter and revealed he had first been diagnosed with stage 3 colon cancer in 2016 two years before the release of Black panther.
His family also revealed that he has been shooting movies the last four years while undergoing chemotherapy treatment.
“A true fighter, Chadwick preserved through it all, and brought you many of the films you have come to love so much.” his family wrote in a statement.
“From Marshall to Da 5 Bloods, August Wildson’s Ma Rainey’s Black Bottom and several more, all were filmed during and between countless surgeries and chemotherapy,” the statement said of the star’s private health struggle.
“It was the honor of his career to bring King T’Challa to life in Black Panther.
“He died in his home, with his wife and family by his side.”
Chadwick’s Marvel co-star Mark Ruffalo – who plays The Hulk – reacted to the devastating news on Twitter.
“All I have to say is the tragedies amassing this year have only been made more profound by the loss of #ChadwickBoseman.
May his soul rest in peace. Amen.